发明名称 |
Unc-13 in the modulation of neurotransmission and secretion events |
摘要 |
The present invention relates to a method for identifying and/or obtaining a molecule which is capable of modifying secretion processes comprising the steps of a) contacting an unc-13 molecule or (a) part(s) or (a) fragment(s) thereof with a candidate molecule; b) measuring and/or detecting a response; and c) comparing said response to a standard response as measured in the absence of said candidate molecule. Furthermore, a method for identifying and/or obtaining a isoform-specific modulator of isoform-specific Munc13 activity is disclosed. The invention also provides for pharmaceutical and diagnostic compositions as well as for uses of antagonist or agonists as identified and/or obtained by the inventive method for the preparation of pharmaceutical and diagnostic compositions.
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申请公布号 |
US2006008800(A1) |
申请公布日期 |
2006.01.12 |
申请号 |
US20040495083 |
申请日期 |
2004.10.28 |
申请人 |
ROSENMUND CHRISTIAN;BROSE NILS;RHEE JEONG-SEON;BETZ ANDREA;RETTIG JENS;ASHERY URI;JUNGE HARALD |
发明人 |
ROSENMUND CHRISTIAN;BROSE NILS;RHEE JEONG-SEON;BETZ ANDREA;RETTIG JENS;ASHERY URI;JUNGE HARALD |
分类号 |
C12Q1/68;A61K38/00;C07H21/04;C07K14/47;C07K14/705;C12N9/02;G01N33/68;G01N33/94 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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