PROCESS FOR PRODUCING PROTEIN A-LIKE PROTEIN WITH USE OF BREVIBACILLUS GENUS BACATERIUM

摘要

An efficient and economically advantageous process for producing a protein A-like protein. In the production of a protein A-like protein utilizing the technology of genetic manipulation, use is made of a host, such as Escherichia coli or Bacillus subtilis, which however results in low productivity becoming a major cause of high cost. Consequently, there is a strong demand on rapid establishment of a technology capable of low-cost mass production of a protein A-like protein with the use of recombinant DNA technology other than that employing Escherichia coli or Bacillus subtilis. Accordingly, there is provided, for example, a process for massproduction of a protein A-like protein, comprising realizing mass secretion expression of the protein with the use of recombinant Brevibacillus genus bacteria into a culture solution and carrying out separation and recovery of accumulated protein A-like protein from the culture solution.