发明名称 |
COMPOSITIONS, METHODS AND KITS RELATING TO HER-2 CLEAVAGE |
摘要 |
<p>The present invention relates to compositions, methods and kits based on the ADAM-mediated cleavage of Her-2. The present invention also relates to treatments for cancer, and in particular, breast cancer, by modulating the ADAM-mediated cleavage of Her-2. Further, the invention relates to compositions, methods and kits based on the surprising synergistic effect between inhibition of Her-2 cleavage by an ADAM and certain cytostatic (e.g., Herceptin) and cytotoxic (e.g., Taxol) compounds in, among other things, inhibiting tumor cell proliferation and inducing cell death. Additionally, the invention relates to novel variants of ADAM15, designated ADAM15 variant 1 and ADAM15 variant 2, now identified and isolated.</p> |
申请公布号 |
EP1613269(A2) |
申请公布日期 |
2006.01.11 |
申请号 |
EP20040758815 |
申请日期 |
2004.04.02 |
申请人 |
INCYTE CORPORATION |
发明人 |
FRIEDMAN, STEVEN, M.;SCHERLE, PEGGY, A.;LIU, XIANGDONG;BURN, TIMOTHY, C.;HUBER, REID;LIU, PHILLIP, C., C.;HOLLIS, GREGORY, F.;VADDI, KRISHNA;FRIDMAN, JORDAN, S. |
分类号 |
A61K39/395;A61K;A61K31/19;(IPC1-7):A61K6/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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