| 摘要 |
A pharmaceutical product comprising one or more elastase inhibitors and one or more growth factors for simultaneous, separate or sequential use to promote wound healing. The elastase inhibitors and growth factors may be combined in a single composition or be present in separate compositions. Growth factors include EGF, PDGF, VEGF, FGF, TGF, IGF-1, tissue growth factor and keratinocyte growth factor. A particularly preferred elastase inhibitor is alpha-1-antitrypsin (AAT), but others include elafin, elastinil, secretory leukocyte proteinase inhibitor or alpha-1-macroglobin. The pharmaceutical product may be topically administered or provided in the form of a wound dressing. An example describes the protective/stabilising effect of AAT on PDGF which is said to synergistically promote wound healing.
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