DEXTROMETHORPHAN DERIVATIVES FOR USE IN INHIBITING LIGAND-GATED ION CHANNEL RECEPTORS
摘要
<p>A computer readable medium holding data of a molecular model of a ligand-gated ion channel receptor and/or a computer system for modeling said receptor are provided by the instant invention. The molecular model can be used to design novel compounds having activity as non-competitive inhibitors of the ion channel. A preferred embodiment of the invention relates to nicotinic acetylcholine receptors. Compounds having activity as non-competitive inhibitors of ligand-gated ion channel receptors and methods for inhibiting the receptor and treating diseases or disorders mediated by function of the receptor are also disclosed.</p>
申请公布号
EP1613271(A2)
申请公布日期
2006.01.11
申请号
EP20040759333
申请日期
2004.04.09
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人
WAINER, IRVING, W.;JOZWIAK, KRZYSZTOF;MOADDEL, RUIN;RAVICHANDRAN, SARANGAN;COLLINS, JACK, R.