发明名称 |
4-HETEROCYCLYSULFONAMIDYL-6-METHOXY-5-(2-METHOXY-PHENOXY)-2-PYRIDYL-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND USE AS ENDOTHELIN RECEPTOR ANTAGONISTS |
摘要 |
The compounds of formula (I) wherein R1 is a heterocyclic residue selected form pyridil and thiazolyl, where said heterocyclic residue may optionally b e substituted with lower alkyl or lower alkenyl; and pharmaceutically acceptab le salts thereof, are inhibitors of endothelin receptors and can therefore be used for the treatment of disorders which are associated with abnormal vascular tone and endothelial dysfunction; and the corresponding intermediat es of formulae (III) and (V).
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申请公布号 |
CA2364906(C) |
申请公布日期 |
2006.01.10 |
申请号 |
CA20002364906 |
申请日期 |
2000.02.28 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
NEIDHART, WERNER;COASSOLO, PHILIPPE;WEISS, PETER;BREU, VOLKER;ROUX, SEBASTIEN |
分类号 |
C07D417/14;A61K31/505;A61K31/506;A61P9/00;C07D401/14 |
主分类号 |
C07D417/14 |
代理机构 |
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主权项 |
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地址 |
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