发明名称 |
BICYCLIC-SUBSTITUTED 4-AMINO-PYRIDOPYRIMIDINE DERIVATIVES |
摘要 |
The invention relates to 6- or 7-bicyclic- substituted 4-amino-substituted pyridopyrimidines of the formula: (see formula 1) (wherein R1 is H or alkyl and R3 is -(CR1R2)m-R4 or -NR1R3 taken together form an indole (or indoline) ring; one of X and Y is N and the other is CR9; R2 is H of alkyl; m is 0 to 6; R4 is aryl or heteroaryl; and R9 is a fused or bridged bicyclic or spirobicyclic ring) and to pharmaceutically acceptable salts, prodrugs and hydrates thereof useful in treating hyperproliferative disorders in a mammal. The invention also relates to pharmaceutical compositions containing the compounds and to methods of treating hyperproliferative disorders abnormal cell growth in a mammal by administering the compounds.
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申请公布号 |
CA2381513(C) |
申请公布日期 |
2006.01.10 |
申请号 |
CA20022381513 |
申请日期 |
2002.04.11 |
申请人 |
PFIZER PRODUCTS INC. |
发明人 |
BHATTACHARYA, SAMIT KUMAR;KATH, JOHN CHARLES;MORRIS, JOEL |
分类号 |
C07D471/04;A61K31/519;A61P9/00;A61P9/14;A61P35/00;A61P35/04;A61P43/00;C07D519/00 |
主分类号 |
C07D471/04 |
代理机构 |
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主权项 |
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地址 |
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