发明名称 |
Transgenic non-human mammals producing fibrinogen in their milk |
摘要 |
A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glands of the animals and secreting the expressed product into a body fluid. Methodology employing such a mammal yields recombinant physiologically functional fibrinogens, subunit chain polypeptides thereof, and modified or fusion fibrinogens.
|
申请公布号 |
US6984772(B1) |
申请公布日期 |
2006.01.10 |
申请号 |
US19950443184 |
申请日期 |
1995.05.17 |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
VELANDER WILLIAM H.;DROHAN WILLIAM N.;LUBON HENRYK;JOHNSON JOHN L. |
分类号 |
C12P21/00;A01K67/00;C12N15/00 |
主分类号 |
C12P21/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|