Indole derivatives as MCP-1 receptor antagonists

摘要

A compound of Formula I, wherein: R¹ is hydrogen, halo, methyl, ethyl or methoxy; R² is hydrogen, halo, methyl, ethyl or methoxy; R³ is a halo group, lower alkyl, lower alkenyl, lower alkynyl, alkoxy, trifluoromethyl, nitro, cyano, trifluoromethoxy, C(O)R⁷, or S(O)_nR⁷ where n is 0, 1 or 2 and R⁷ is an alkyl group; R⁴ is a halo, trifluoromethyl, methylthio, methoxy, trifluoromethoxy or lower alkyl, lower alkenyl or lower alkynyl or COR⁸ where R⁸ is lower alkyl; R⁶ is hydrogen, halo, lower alkyl, lower alkenyl, lower alkynyl or COR⁹ where R⁹ is lower alkyl; provided that when R¹ is hydrogen, halo or methoxy, R² is hydrogen, halo, methyl, ethyl or methoxy, R⁵ and R⁶ are both hydrogen, and one of R³ or R⁴ is not halo or trifluoromethyl; or a pharmaceutically acceptable salt or prodrug thereof. These compounds have useful activity for the treatment of inflammatory disease, specifically in antagonizing an MCP-1 mediated effect in a warm-blooded animal such as a human being.