| 发明名称 |
Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha |
| 摘要 |
The present application describes novel cyclic beta-amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NR<SUP>a</SUP>, and S(O)<SUB>p</SUB>, and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease and/or as TNF-alpha inhibitors.
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| 申请公布号 |
US6984648(B2) |
申请公布日期 |
2006.01.10 |
| 申请号 |
US20040779539 |
申请日期 |
2004.02.13 |
| 申请人 |
BRISTOL-MYERS SQUIBB PHARMA COMPANY |
发明人 |
LU ZHONGHUI;MADUSKUIE, JR. THOMAS P.;VOSS MATTHEW E.;XUE CHU-BIAO;DUAN JINGWU;OTT GREGORY;CHEN LIHUA;DECICCO CARL |
| 分类号 |
A61K31/47;C07D215/22;A61K31/16;A61K31/44;A61K31/445;A61K31/4725;A61K31/5377;A61K31/55;A61P1/02;A61P1/04;A61P1/16;A61P7/02;A61P9/00;A61P9/04;A61P11/00;A61P11/06;A61P17/00;A61P17/06;A61P19/02;A61P19/06;A61P21/04;A61P25/28;A61P25/32;A61P27/02;A61P27/06;A61P29/00;A61P31/00;A61P31/04;A61P31/06;A61P31/18;A61P35/00;A61P35/04;A61P37/02;A61P43/00;C07C259/08;C07D211/68;C07D213/38;C07D213/56;C07D213/81;C07D213/82;C07D215/02;C07D215/12;C07D215/14;C07D223/12;C07D261/02;C07D261/04;C07D307/18;C07D307/24;C07D401/06;C07D401/12;C07D401/14;C07D405/12;C07D405/14;C07D409/14;C07D413/00;C07D413/04;C07D413/12;C07D417/12;C07D417/14 |
主分类号 |
A61K31/47 |
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