| 发明名称 |
Anaerobe targeted enzyme-mediated prodrug therapy |
| 摘要 |
Recombinant anaerobic bacterial compositions that under anaerobic conditions present in a solid tumor and produce an enzyme capable of catalyzing the conversion of a prodrug to its cytotoxic product in situ are described. Methods of treating tumors using the composition are also described. |
| 申请公布号 |
US6984513(B2) |
申请公布日期 |
2006.01.10 |
| 申请号 |
US20020158976 |
申请日期 |
2002.05.31 |
| 申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
BROWN JOHN M.;LIU SHIE-CHAU;GIACCIA AMATO J.;MINTON NIGEL P. |
| 分类号 |
C12N1/20;A01N63/00;A61K35/74;A61K48/00;C12N1/21;C12N9/02;C12N15/74 |
主分类号 |
C12N1/20 |
| 代理机构 |
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代理人 |
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| 主权项 |
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