摘要 |
A 2-5A analog represented by the formula (1): <CHEM> Äwherein m is 0 or 1; n is 0 to 2; R<1> represents an alkoxy group having from 1 to 6 carbon atoms which may have a substituent, a mercapto group, a mercapto group protected by a nucleic acid synthesis protecting group, or an alkylthio group having from 1 to 4 carbon atoms which may have a substituent; R<2>, R<3>, R<4>, R<5> and R<6> represent a hydroxyl group, a hydroxyl group protected by a nucleic acid synthesis protecting group, an alkoxy group having from 1 to 6 carbon atoms which may have a substituent, a mercapto group, a mercapto group protected by a nucleic acid synthesis protecting group, or an alkylthio group having from 1 to 4 carbon atoms which may have a substituent; R<7> represents an oxygen atom, or a -O(CH2CH2O)q- group (q is 2 to 6); R<8> represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms which may have a substituent, or 5'-phosphorylated oligonucleotide analogs which do not have one hydroxyl group on a 5'-phosphoric acid group; E<1>, E<2>, E<3> and E<4> represent a naturally occurring or modified nucleic acid unitÜ, and a pharmacologically acceptable salt thereof. |