发明名称 |
COMPOUNDS AND THEIR USE FOR SPECIFIC AND SIMULTANEOUS INHIBITION OF GENES INVOLVED IN DISEASES AND RELATED DRUGS |
摘要 |
The invention relate to the use of a compound of formula A-B-C Wherein A is a DNA sequence-specific ligand capable of simultaneously and specifically recognizing a sequence common to genes of pathological interest; B is a linker arm, said linker arm being bound to the 3' end of A; C is a topoisomerase I posion; for the preparation of a drug for the treatment of a disease brought about by the expression of a gene and said gene is inhibited by the stabilized topoisomerase I-mediated DNA cleavage. Application, particularly, for the treatment of infective microorganism or virus, dismetabolic disease and autoimmune disease.
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申请公布号 |
KR20060002827(A) |
申请公布日期 |
2006.01.09 |
申请号 |
KR20057017431 |
申请日期 |
2005.09.16 |
申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE(INSERM);CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);MUSEUM NATIONAL D'HISTOIRE NATURELLE |
发明人 |
ARIMONDO PAOLA BARBARA;BOUTORINE ALEXANDRE;SUN JIAN SHENG;BAILLY CHRISTIAN;HELENE CLAUDE;GARESTIER THERESE |
分类号 |
C12N15/62;A61K38/00;A61K48/00;A61P35/00;C12N15/113 |
主分类号 |
C12N15/62 |
代理机构 |
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地址 |
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