| 摘要 |
PROBLEM TO BE SOLVED: To provide new vitamin D analogues, their production method, medicinal preparations comprising these compounds, and use of them for medicines. SOLUTION: The vitamin D analogues lack the combined presence of the trans-fused six-membered C-ring and of five-membered D-ring, but still possess a central part consisting of a substituted chain of five atoms which correspond to positions 8, 14, 13, 17 and 20 of vitamin D, and the ends of which are connected, at position 20 a structural moiety representing part of the side-chain of vitamin D or of an analogue of vitamin D, and at position 8 theΔ(5,7)-diene moiety connected to the A-ring of the active 1-α-hydroxy metabolite or of an established vitamin D analogue. COPYRIGHT: (C)2006,JPO&NCIPI |
