Process for the preparation of 4-(3'-chloro-4'-fluoroanilino) -7-methoxy-6- (3-morpholinopropoxy) quinazoline

摘要

The invention relates to chemical processes and intermediates useful in the manufacture of the quinazoline derivative 4(3' chloro 4' fluoroanilino)-7-methoxy-6-(3-morpholinopropoxyquinazoline. In particular, the invention relates to processes for the manufacture of 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one of Formula (II) and 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile of Formula (III) and their use in the manufacture of said quinazoline derivative.