发明名称 |
Automated separation, purification and labeling system for 60Cu, 61Cu and 64Cu radionuclides and recovery thereof |
摘要 |
A novel method for separating an irradiated <SUP>60</SUP>Cu or <SUP>61</SUP>Cu or <SUP>64</SUP>Cu respectively from a composition containing <SUP>60</SUP>Ni or <SUP>61</SUP>Ni or <SUP>64</SUP>Ni respectively therein comprises dissolving the irradiated <SUP>60</SUP>Cu or <SUP>61</SUP>Cu or <SUP>64</SUP>Cu in a solvent acid to form an acidic solubilized composition, feeding the acidic solubilized composition onto an ion exchange column and removing an eluent comprising <SUP>60</SUP>Ni or <SUP>61</SUP>Ni or <SUP>64</SUP>Ni ions. In an aspect the eluent is further processed for <SUP>60</SUP>Ni or <SUP>61</SUP>Ni or <SUP>64</SUP>Ni recovery and recycling to prepare future targets. In an aspect <SUP>60</SUP>Cu or <SUP>61</SUP>Cu or <SUP>64</SUP>Cu respectively is temporarily trapped into the ion exchange column resin and held for subsequent recovery by addition of 0.5 N HCl to elute out the <SUP>60</SUP>Cu or <SUP>61</SUP>Cu or <SUP>64</SUP>Cu for further use or labeling. An enhanced process for labeling compounds with highly purified <SUP>60</SUP>Cu, <SUP>61</SUP>Cu or <SUP>64</SUP>Cu comprises loading <SUP>60</SUP>Cu, <SUP>61</SUP>Cu and <SUP>64</SUP>Cu elute onto a concentrating cartridge, collecting the 0.5N HCl eluent and admixing therewith 10-muL of ligand and 3N HCl solution in a reaction line to form a <SUP>60 or 61 or 64</SUP>Cu labeled product. In an aspect a further purification step comprises loading 10-mL sterile water into the reaction line and through the C<SUB>18 </SUB>Sep-Pak cartridge to further purify the labeled product which is adherent in the cartridge and recovering <SUP>60</SUP>Cu, <SUP>61</SUP>Cu and <SUP>64</SUP>Cu each as a separate and independent purified product.
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申请公布号 |
US2006004491(A1) |
申请公布日期 |
2006.01.05 |
申请号 |
US20040914617 |
申请日期 |
2004.08.09 |
申请人 |
WELCH MICHAEL J;TANG LUCIE L W;GAEHLE GREGORY G;LEWIS JASON S |
发明人 |
WELCH MICHAEL J.;TANG LUCIE L.W.;GAEHLE GREGORY G.;LEWIS JASON S. |
分类号 |
G05B21/00;C07C |
主分类号 |
G05B21/00 |
代理机构 |
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代理人 |
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