发明名称 ß-CYCLODEXTRIN DERIVATIVES AND THEIR USE AGAINST ANTHRAX LETHAL TOXIN
摘要 The invention provides low molecular weight compounds that block the pore formed by protective antigen and inhibit anthrax toxin action. Structures of the compounds are derivatives of ß-cyclodextrin. Per-substituted alkylamino derivatives displayed inhibitory activity, and they were protective against anthrax lethal toxin action at low micromolar concentrations. Also, the addition of one of the alkylamino derivatives to the bilayer lipid membrane with multiple PA channels caused a significant decrease in membrane conductance. Thus, the invention also provides method for protection against anthrax toxicity.
申请公布号 WO2006001844(A2) 申请公布日期 2006.01.05
申请号 WO2005US03545 申请日期 2005.01.28
申请人 PINNACLE PHARMACEUTICALS;INNOVATIVE BIOLOGICS, INC.;ADVANCED BIOSYSTEMS, INC. 发明人 KARGINOV, VLADIMIR, A.;HECHT, SIDNEY, M.;FAHMI, NOUREDDINE;ALIBEN, KEN
分类号 A61K31/724 主分类号 A61K31/724
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