PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH A CYCLIC AMINO GROUP AS CRF ANTAGONISTS

摘要

[PROBLEM TO BE SOLVED] An object of the present invention is to provide an
antagonist against CRF receptors and/or an agonist for receptors which is
effective as a therapeutic or prophylactic agent for diseases in which CRF is
considered to be involved, such as depression, anxiety, Alzheimer''s disease,
Parkinson''s disease, Huntington''s chorea, eating disorder, hypertension,
gastrointestinal diseases, drug dependence, cerebral infarction, cerebral
ischemia, cerebral edema, cephalic external wound, inflammation, immunity-
related diseases, alopecia, irritable bowel syndrome, sleep disorders,
epilepsy, dermatitides, schizophrenia, pain, etc. [SOLUTION] A
pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic
amino group represented by the following formula [I] has a high affinity for
CRF receptors and/or .delta. receptors, and is effective against diseases in
which CRF is considered to be involved.