| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a method for measuring and retrieving ingredients, having the ability to inhibit carcinoma metastasis and measuring the degree of their metastasis inhibition, in a carcinoma metastasis model system reflecting in-vivo kinetics in an initial phase-surrounding carcinoma cells and vascular endothelial cells from a view point on the side of host cells for the purpose of screening drugs having a metastasis inhibiting action for prognostic improvements, regarding patients who have experienced carcinoma detection and extirpative surgery, and to provide a measuring instrument. <P>SOLUTION: In this method, to coexistently culture both the vascular endothelial cells (5) and the carcinoma cells without direct contact, supply ingredients involved in a cleavage degree part (9) of the vascular endothelial cells considered as secreting from carcinoma cells, and measure the degree of its cleavage by measuring the electrical resistance level between an upper layer part (7) and a lower layer part (8) of a culture compartment. The carcinoma metastasis inhibition ability measuring instrument uses this measuring method. <P>COPYRIGHT: (C)2006,JPO&NCIPI</p> |
