发明名称 |
NOVEL INDAZOLE CARBOXAMIDES AND THEIR USE |
摘要 |
The invention is directed to novel indazole carboxamide derivatives. Specifically, the invention is directed to compounds according to Formula (I), wherein R1 and Z are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKß) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. |
申请公布号 |
WO2006002434(A2) |
申请公布日期 |
2006.01.05 |
申请号 |
WO2005US22870 |
申请日期 |
2005.06.24 |
申请人 |
SMITHKLINE BEECHAM CORPORATION;KERNS, JEFFREY, K.;EDWARDS, CHRISTINE |
发明人 |
KERNS, JEFFREY, K.;EDWARDS, CHRISTINE |
分类号 |
A61K31/454;C07D403/02 |
主分类号 |
A61K31/454 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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