DIAGNOSTIC AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH RHO-ASSOCIATED PROTEIN KINASE 2 (ROCK2)

摘要

The invention provides a human ROCK2 which is associated with cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastro­enterological diseases, cancer, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases, reproduction diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, muscle-skeleton diseases, neurological diseases, reproduction diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of ROCK2 as well as pharmaceutical compositions comprising such compounds.