发明名称 |
Membrane-anchored beta2 microglobulin covalently linked to mhc class 1 peptide epitopes |
摘要 |
The invention provides a polynucleotide comprising a sequence encoding a polypeptide comprising a beta2-microglobulin molecule linked through its carboxyl terminal to a polypeptide stretch that allows the anchorage of the beta2-microglobulin molecule to the cell membrane, and through its amino terminal to at least one antigenic peptide comprising a MHC class I epitope, wherein said antigenic peptide is not related to an autoimmune disease and is preferably derived from a tumor-associated antigen or from a pathogenic antigen. Antigen presenting cells, and DNA and cellular vaccines for treatment of cancer and infectious diseases, are also provided.
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申请公布号 |
US2006003315(A1) |
申请公布日期 |
2006.01.05 |
申请号 |
US20040517784 |
申请日期 |
2004.12.13 |
申请人 |
GAVISH-GALILEE BIO APPLICATIONS LTD. |
发明人 |
GROSS GIDEON;MARGALIT ALON |
分类号 |
C12Q1/70;C07H21/04;C07K14/16;C07K14/74;C12N15/62;C12Q1/68 |
主分类号 |
C12Q1/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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