发明名称 |
PROCESS FOR PRODUCING 2'-DEOXY-2'-FLUOROURIDINE |
摘要 |
<p>1-²-D-Arabinofuranosyluracil in 3',5'-hydroxyl-protected form is reacted with a trifluoromethanesulfonylating agent in the presence of an organic base to convert it into a 2'-triflate form, and then it is reacted with a fluorinating agent containing "a salt or complex formed by an organic base and hydrofluoric acid" to produce 2'-deoxy-2'-fluorouridine in 3',5'-hydroxyl-protected form. A deprotecting agent is further caused to act thereon to obtain 2'-deoxy-2'-fluorouridine. The 2'-deoxy-2'-fluorouridine obtained can efficiently be purified by temporarily converting it into a 3',5'-diacetyl form, recrystallizing the 3',5'-diacetyl form, and then deacetylating it. Thus, high-purity 2'-deoxy-2'-fluorouridine can be produced.</p> |
申请公布号 |
EP1612213(A1) |
申请公布日期 |
2006.01.04 |
申请号 |
EP20040726789 |
申请日期 |
2004.04.09 |
申请人 |
CENTRAL GLASS COMPANY, LIMITED |
发明人 |
ISHII, AKIHIRO;OOTSUKA, TAKASHI;KANAI, MASATOMI;KURIYAMA, YOKUSU;YASUMOTO, MANABU;INOMIYA, KENJIN;UEDA, KOJI |
分类号 |
C07H19/067;(IPC1-7):C07H19/067 |
主分类号 |
C07H19/067 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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