发明名称 |
Method of complexing a nucleic acid with a lipid-conjugated polyamide |
摘要 |
In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.
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申请公布号 |
US6982092(B2) |
申请公布日期 |
2006.01.03 |
申请号 |
US20030448902 |
申请日期 |
2003.05.30 |
申请人 |
CHIRON CORPORATION |
发明人 |
ZUCKERMANN RONALD N.;HUANG CHIN-YI;MURPHY JOHN E.;UNO TETSUO |
分类号 |
A61K9/127;C12N15/09;A61K31/711;A61K47/16;A61K47/34;A61K47/48;A61K48/00;C07C231/02;C07C237/22;C07H21/04;C07J9/00;C08G69/48;C08K5/21;C11C3/00;C12N15/87 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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