Cyanopyrroles

摘要

This invention provides a progesterone receptor antagonist of formula 1 having the structure wherein T is O, S, or absent; R₁, and R₂ are each, independently, hydrogen, alkyl, substituted alkyl; or R₁ and R₂ are taken together form a ring and together contain -CH₂(CH₂)_nCH₂-, -CH₂CH₂CMe₂CH₂CH₂-, -O(CH₂)_pCH₂-, -O(CH₂)_qO-, -CH₂CH₂OCH₂CH₂-, or -CH₂CH₂NR₇CH₂CH₂-; n=1-5; p=1-4; q=1-4; R₃ is hydrogen, OH, NH₂, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or COR^A; R^A is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R₄ is hydrogen, halogen, CN, NH₂, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R₅ is hydrogen, alkyl, or substituted alkyl; R₆ is hydrogen, alkyl, substituted alkyl, or COR^B; R^B is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R₇ is hydrogen or alkyl, or a pharmaceutically acceptable salt thereof.