METHODS OF IDENTIFYING ANTINEOPLASTIC AGENTS

摘要

The expression of particular genes is altered in response to treatment of cancer cells with a DNA damaging agent and a Chk1 inhibitor. Expression of such genes, termed "surrogate marker genes," can be used to identify test compounds as potential antineoplastic agents, to assess the potential in vivo efficacy of such agents, and to monitor clinical efficacy of treatment with Chk1 inhibitors.