Agents and methods for the treatment of disorders associated with oxidative stress

摘要

The invention provides a method for preventing or reducing the effects of oxidative stress on a substrate. The method includes the step of treating the substrate with a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein: R¹ is one or more substituents selected from -H, -alkyl, -alkoxy, -aryl, -aryloxy, -halogen, -amino (mono-, di- and tri-substituted), -alkylthio, -NO₂, -COOH, -COOAlkyl, -CO-alkyl, -CN; R² is one or more substituents selected from -H, -alkyl, -(CH₂CH₂O)n-R⁵, a sugar moiety; R³ is -H, -alkyl, -aryl, -alkylOR⁶, -alkylC(O)R⁶; R⁵ is selected from -H, -alkyl, -aryl; and R⁴ and R⁶ are independently selected from -OH, -O-alkyl, -O-polyalkyleneoxy, -O-aryl, -OC(O)O-alkyl, -S-alkyl and -amino.