USE OF GLUT1 TRANSPORTER EXPRESSED IN BLOOD BRAIN BARRIER CELLS FOR SCREENING FOR PHARMACOLOGICALLY ACTIVE SUBSTANCES

摘要

GLUT1 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is actively transported by, the GLUT1 transporter, and therefore a candidate substrate for crossing the blood brain barrier. The assays are useful in screening for therapeutic, cytotoxic or imaging compounds used in the treatment or diagnosis of neurological diseases.