PROCESS FOR PRODUCING A CAPSULAR POLYSACCHARIDE FOR USE IN CONJUGATE VACCINES

摘要

The present invention relates to a method for producing a polysaccharide and a conjugate vaccine comprising the polysaccharide produced according to the method of the invention. A characteristic step in the method according to the invention is that the pH of the culture medium is kept at a constant value with base or acid until adjustment with respectively base or acid is not possible anymore. Using the method of the inven­tion, capsular polysaccharide may be obtained in a high yield in a relatively short time. The method is straightforward, reproducible and cost-effective.