发明名称 |
NOVEL ANTI-DC-SIGN ANTIBODIES |
摘要 |
Antibodies to DC-SIGN are disclosed which are capable of modulating the interaction of dendritic cells and T cells. In some embodiments, the antibodies inhibit the interaction of dendritic cells and T cells. In other embodiments, the antibodies are combined with peptides which are internalized in dendritic cells and presented to T cells, thereby generating an immune response to the peptide. The antibodies of the present disclosure may, in some embodiments, be useful in blocking viral binding, infection, and transmission. |
申请公布号 |
WO2005058244(A3) |
申请公布日期 |
2005.12.29 |
申请号 |
WO2004US41788 |
申请日期 |
2004.12.15 |
申请人 |
ALEXION PHARMACEUTICALS, INC.;BOWDISH, KATHERINE, S.;KRETZ-ROMMEL, ANKE |
发明人 |
BOWDISH, KATHERINE, S.;KRETZ-ROMMEL, ANKE |
分类号 |
A61K;A61K45/00;A61K47/00;A61K47/48;C07K16/00;C07K16/28;C12P21/08;G01N33/53;G01N33/564;G01N33/574 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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