| 摘要 |
A compound of formula (I): where R1 = an aryl, heteroaryl or alkyl group, optionally substituted with a group of formula -(CO)-CR6R7NR8R9, where R6, R7, R8 and R9 are as defined in the description, R2 = H or optionally substituted alkyl, R3 = H or optionally substituted alkyl, R4 = H or optionally substituted alkyl, or R3 and R4 form, together with the carbon of attachment, an optionally substituted, 3- to 18-membered, saturated or unsaturated mono-, bi- or tri-cyclic system, optionally comprising one or several heteroatoms selected from O, S and N, n = 0, 1 or 2, Ar = aryl or heteroaryl group and R5 = optionally substituted amino, guanidino, cyano or amidino, the optical isomers and addition salts thereof with a pharmacologically acceptable acid. The above are of application as medicaments.
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