ALTERATION OF FCRN BINDING AFFINITIES OR SERUM HALF-LIVES OF ANTIBODIES BY MUTAGENESIS
摘要
The present invention provides for a modified antibody of class IgG, in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that present in the unmodified antibody, thereby altering the binding affinity for FcRn and/or the serum half-life in comparison to the unmodified antibody.
申请公布号
WO2005123780(A2)
申请公布日期
2005.12.29
申请号
WO2005US11996
申请日期
2005.04.08
申请人
PROTEIN DESIGN LABS, INC.;HINTON, PAUL, R.;TSURUSHITA, NAOYA;TSO, YUN, J.;VASQUEZ, MAXIMILIANO
发明人
HINTON, PAUL, R.;TSURUSHITA, NAOYA;TSO, YUN, J.;VASQUEZ, MAXIMILIANO