| 摘要 |
<p>The present invention relates to a lentivirus based DNA vector comprising a bacterial selection marker, a bacterial origin of replication and recognition sequences for endonucleases suitable for receiving a transgene, wherein the recognition sequences for endonucleases are arranged between two lentivirus-derived LTR sequences, at least one of which carries a deletion of the U3 gene making it self-inactivating (SIN), characterized in that the vector comprises, arranged between two lentivirus-derived LTR sequences, a lentiviral packaging signal (Psi) and at least one homing endonuclease recognition site for receiving at least one expression cassette comprising a transgene.</p> |
