A MODIFIED BACULOVIRUS EXPRESSION SYSTEM FOR PRODUCTION OF PSEUDOTYPED RAAV VECTOR

摘要

The invention provides modifications to a baculovirus-based recombinant adeno associated virus (AAV) system including enhancement of the helper virus stability and construction of novel baculovirus vectors for rAAV pseudotyping. The modified system extends the flexibility of rAAV vector production and promotes the utility of AAV as a clinically applicable gene therapy vector.