LIPOSOME PREPARATION CONTAINING SLIGHTLY WATER-SOLUBLE CAMPTOTHECIN

摘要

The invention aims at providing a slightly water-soluble camptothecin liposome preparation which permits long-term stable retention of a slightly water-soluble camptothecin therein to thereby inhibit the alpha-hydroxylactone ring from hydrolysis in blood and keep the camptothecin in the cyclic state contributing to the antitumor activity and which is improved in the releasability of the camptothecin from liposome and is therefore so excellent in the residence of the camptothecin in blood that the concentration of the camptothecin in plasma can be kept for a long time after administration. This aim is attained by a liposome preparation which contains a fatty acid and a phospholipid as the lipid components constituting the membrane and a slightly water-soluble camptothecin as the drug.