NOVEL ANALOGS OF 3-O-ACETYL-11-KETO-beta-BOSWELLIC ACID
摘要
<p>This invention relates to analogs of 3-0-Acetyl-11-Keto-b-Boswellic acid (AKBA) that exhibit 5-Lipoxigenase inhibitory properties. These compounds may be used in pharmaceutical compositions for therapeutic applications against a variety of inflammations and hypersensitivity-based human diseases including asthma, arthritis, bowel diseases such as ulcerative colitis and circulatory disorders such as shock and ischemia. These compounds also inhibited the growth of brine shrimp in cultures, which may be considered as a positive indication for cytotoxicity and antitumor activity.</p>