| 摘要 |
<p>There is provided a T-type calcium channel blocker that is optically active 1,4-dihydropyridine compound, a pharmaceutically acceptable salt thereof or a solvate thereof, of formula (1) <CHEM> wherein R<1> and R<2> are independently of each other C1-6 alkyl group or R<1> and R<2> together form -CR<5>R<6>-CR<7>R<8>-, -CR<5>R<6>-CR<7>R<8>-CR<9>R<10>- or -CR<5>R<6>-CR<7>R<8>-CR<9>R<10>-CR<11>R<12>-, etc., X<1> and X<2> are independently of each other O or NR<13>, Ar is optionally substituted phenyl group, etc., R<a> and R<b> are independently of each other C1-6 alkyl group, -L<2>-NR<16>R<17>, CH2O-L<2>-NR<16>R<17>, CN, -L<2>-N(CH2CH2)2NR<16> or NR<16>R<17> etc., Y is C1-20 alkyl group, -L<3>-NR<18>R<19> <CHEM> <CHEM> and * is absolute configuration of R.</p> |
