| 发明名称 |
2-PHENOXY- AND 2-PHENYLSULFOMAMIDE DERIVATIVES WITH CCR3 ANTAGONISTIC ACTIVITY FOR THE TREATMENT OF ASTHMA AND OTHER INFLAMMATORY OR IMMUNOLOGICAL DISORDERS |
| 摘要 |
<p>The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of disease associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
wherein
X represents O or S;
R 4 represents
the other substituents are as defined in claim 1.</p> |
| 申请公布号 |
EP1608374(A1) |
申请公布日期 |
2005.12.28 |
| 申请号 |
EP20040719389 |
申请日期 |
2004.03.11 |
| 申请人 |
ACTIMIS PHARMACEUTICALS, INC. |
发明人 |
LI, YINGFU;BACON, KEVIN;SUGIMOTO, HIROMI;FUKUSHIMA, KEIKO;HASHIMOTO, KENTARO;MARUMO, MAKIKO;MORIWAKI, TOSHIYA;NUNAMI, NORIKO;TSUNO, NAOKI;URBAHNS, KLAUS;YOSHIDA, NAGAHIRO |
| 分类号 |
A61K31/4015;A61K31/405;A61K31/439;A61K31/4965;A61K31/497;C07C311/29;C07C311/37;C07D207/12;C07D207/14;C07D207/16;C07D207/34;C07D207/40;C07D207/404;C07D211/54;C07D223/12;C07D241/04;C07D243/08;C07D257/04;C07D295/13;C07D295/26;C07D303/06;C07D401/04;C07D401/06;C07D403/04;C07D403/06;C07D453/02;C07D487/04;(IPC1-7):A61K31/496;A61K31/401 |
主分类号 |
A61K31/4015 |
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