发明名称 |
Hepatitis B virus (HBV) variants |
摘要 |
<p>The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus variants exhibiting complete or partial resistance to nucleoside analogues and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic regimes and in developing new or modified vaccines directed against viral agents and in particular hepatitis B virus variants.</p> |
申请公布号 |
EP1609865(A2) |
申请公布日期 |
2005.12.28 |
申请号 |
EP20050076547 |
申请日期 |
2000.04.07 |
申请人 |
MELBOURNE HEALTH |
发明人 |
BARTHOLOMEUSZ, ANGELINE;LITTLEJOHN, MARGARET;AYRES, ANNA;LOCARNINI, STEPHEN |
分类号 |
A61K39/00;A61K39/29;C07K14/02;C07K16/08;C12N7/00;C12N7/01;C12N15/13;C12N15/36;(IPC1-7):C12N15/13 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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