| 发明名称 |
A SEMI-SYNTHETIC PROCESS FOR THE PREPARATION OF N DEBENZOYLPACLITAXEL |
| 摘要 |
<p>A process for the preparation of N-debenzoylpaclitaxel (I) through esterification of 7-protected baccatin III with a carboxylic acid reactive derivative of general formula (II), and elimination of the ester-protecting groups in acid conditions and in a single step. In formula (II) R1 is aryl or heteroaryl. The compound of formula (I) can be conveniently used for the preparation of paclitaxel and analogues</p> |
| 申请公布号 |
EP1495011(B1) |
申请公布日期 |
2005.12.28 |
| 申请号 |
EP20030714874 |
申请日期 |
2003.03.24 |
| 申请人 |
INDENA S.P.A. |
发明人 |
BOMBARDELLI, EZIO;FONTANA, GABRIELE |
| 分类号 |
C07B51/00;C07B61/00;C07D263/04;C07D263/06;C07D305/14;C07D413/12;(IPC1-7):C07D305/14 |
主分类号 |
C07B51/00 |
| 代理机构 |
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代理人 |
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| 主权项 |
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