发明名称 |
Methods of use of viral vectors to deliver antigen to dendritic cells |
摘要 |
This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing T antigen specific cytotoxic T lymphocytes. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are provided to dendritic cells using a viral vector such as influenza virus which may be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are infected with the vector are then capable of presenting the antigen and inducing cytotoxic T-lymphocyte activity or may also be used as vaccines.
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申请公布号 |
US2005282282(A1) |
申请公布日期 |
2005.12.22 |
申请号 |
US20050187314 |
申请日期 |
2005.07.21 |
申请人 |
STEINMAN RALPH M;BHARDWAJ NINA;BENDER ARMIN |
发明人 |
STEINMAN RALPH M.;BHARDWAJ NINA;BENDER ARMIN |
分类号 |
A61K39/00;A61K39/145;C12N5/08;C12N7/04;C12N15/86;(IPC1-7):C12N15/86 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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