Inhibitors of epoxide hydrolases for the treatment of hypertension

摘要

The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula I wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R₁-R₄ is hydrogen, R₂ is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R₄ is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R₁ and R₃ is each independently C₁-C₂₀ substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.