Biodegradable poly(ester-amides) are synthesized from amino acids, diols and dicarboxylic acids where one or both of the diols and dicarboxylic acids contain unsaturation; e.g., from di-p-nitrophenyl dicarboxylates and p-toluenesulfonic acid salts of bis(alpha-amino acid) disesters of diols where one or both of the dicarboxylate and diol moieties contain unsaturation or from di-p-nitrophenyl dicarboxylates, and p-toluene-sulfonic acid salts of bis(alpha-amino acid) diesters of diols and p-toluenesulfonic acid salt of lysine ester where one or both of the dicarboxylate and diol moieties contain unsaturation. The polymers are useful as biodegradable carriers for drugs of other bioactive agents.
申请公布号
WO2005121250(A2)
申请公布日期
2005.12.22
申请号
WO2005US19088
申请日期
2005.05.31
申请人
CORNELL RESEARCH FOUNDATION, INC.;CHU, CHIH-CHANG;GUO, KAI;KATSARAVA, RAMAZ