2H OR 3H-BENZO[E]INDAZOL-1-YLE CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF

摘要

The invention relates to compounds of formula (I), wherein W is an oxygen or sulphur atom, each X, X2, X3 and X4 independently represents a hydrogen or halogen atom or a cyano, C,-C6-alkyl, C,-C6-fluoralkyl, C,-C6-alkoxy, C,-C6-fluoroalkoxy group, Y is in position (N2) or (N3); when Y is in the (N2) position, Y represents a C,-C6-alkyl, C,-C6-fluoralkyl, aryl or heteroaryl group; when Y is in the (N3) position, Y represents an aryl or heteroaryl group; the aryl and heteroaryl groups are possibly substituted by one or several atoms or groups selected from halogen atoms, C,-C6-alkyl, C,-C6-alkoxy, C,-C6-alkylthio, C,-C6-alkyl-S(O)-, C,-C6-alkyl-S(0)2-, C,-C6-fluoralkyl groups; a C4-C5 position bond is double or single; each R1 et R2 independently represents an aryl, benzyl or C,-C6-alkyl group or R1 et R2 form, with a nitrogen atom carrier thereof, a heterocycle possibly substituted by one or several C1-C6-alkyl or benzyl groups in the form of a base, an acid addition salt, a hydrate or a solvate. A method for preparation and therapeutic use is also disclosed.