GLYCOSYLPHOSPHATIDYLINOSITOL GLYCAN SIGNALLING VIA INTEGRINS FUNCTIONING AS GLYCAN SPECIFIC RECEPTORS

摘要

The present invention relates generally to a method of modulating integrin-mediated cellular activity and to agents useful for same. More particularly, the present invention contemplates a method of modulating ab integrin-mediated cellular activity by modulating GPI-related signalling. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate integrin-mediated cellular activity. The present invention is further directed to methods for identifying and/or designing agents capable of modulating the subject integrin dependent signalling mechanism.