NOVEL SULFONAMIDES AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE

摘要

Disclosed herein are carbonyl compounds of having the structural formula (I)
or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof,
Methods and compositions are disclosed for treating disease states including,
but not limited to cancers, autoimmune diseases, tissue damage, central
nervous system disorders, neurodegenerative disorders, fibrosis, bone
disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory
conditions, cardiovascular conditions, and disorders in which angiogenesis
play a role in pathogenesis, using the compounds of the invention. In
addition, methods of modulating the activity of histone deacetylase (HDAC) are
also disclosed.