Process for preparing a cross-linked carboxyl polysaccharide and the cross-linked carboxyl polysaccharide

摘要

A process for preparing a cross-linked polysaccharide comprises providing a polysaccharide with free carboxyl and hydroxyl groups capable of forming an intermolecular ester bond and cross-linking the polysaccharide by using onium salt, phosphonium salt, uronium salt or carbenium salt and in the presence or in the absence of organic base as cross-link reagent to obtain a highly cross-linked polysaccharide. The cross-linked polysaccharide has high cross-linking density and is stable and slowly biodegradable.