ACETHYLCHOLINESTERASE(ACHE) VARIANTS OF THE N-TERMINUS

摘要

A novel form of acetylcholinesterase (AChE) is provided, N-AChE, which bears a transmembrane domain. Exons encoding this novel form, the peptide comprising the transmembrane domain, as well as antibodies which recognize this novel form are also provided. N-AChE expression in the hippocampus is correlated with Alzheimer's disease, and its detection using the anti-N-AChE antibodies may be a new diagnostic method for this disease.