The preservation of live viral vaccines is disclosed. These liquid formulations comprise a live virus and a preservative, namely chlorobutanol. The preserved, live virus formulations of the present invention are (1) suitable for a vaccine or gene therapy product with a multi-dose image; (2) compatible with parenteral administration; and (3) are stable for extended periods of time with negligible loss of activity.
申请公布号
WO2005052116(A3)
申请公布日期
2005.12.22
申请号
WO2004US38670
申请日期
2004.11.18
申请人
MERCK & CO., INC.;EVANS, ROBERT, K.;YIN, DANIEL, H.