发明名称 |
TRANS-MEMBRANE-ANTIBODY INDUCED INHIBITION OF APOPTOSIS |
摘要 |
<p>Cell suicide (apoptosis) is associated with pathogenesis, for example, it is the major cause for the loss of neurons in Alzheimer's disease. Caspase-3 is critically involved in the pathway of apoptosis. Superantibody (SAT)-trans-membrane technology has been used to produce antibodies against the caspase enzyme in an effort to inhibit apoptosis in living cells. The advantage of using trans-membrane antibodies as apoptosis inhibitors is their specific target recognition in the cell and their lower toxicity compared to conventional apoptosis inhibitors. It is shown that a MTS-transport-peptide modified monoclonal anti-caspase-3 antibody reduces actinomycin D-induced apoptosis and cleavage of spectrin in living cells. These results indicate that antibodies conjugated to a membrane transporter peptide have a therapeutic potential to inhibit apoptosis in a variety of diseases.</p> |
申请公布号 |
EP1605893(A2) |
申请公布日期 |
2005.12.21 |
申请号 |
EP20040718110 |
申请日期 |
2004.03.05 |
申请人 |
INNEXUS BIOTECHNOLOGY INC.;IMMPHERON INCORPORATED |
发明人 |
KOHLER, HEINZ;MULLER, SYBILLE;BROWN, THOMAS, L.;ZHAO, YUNFENG;MORGAN, ALTON C., JR. |
分类号 |
C07K16/00;A61K;A61K6/00;A61K38/10;A61K39/104;A61K39/395;A61K39/44;A61K47/42;A61K47/48;A61K51/10;C07K7/08;C07K16/28;C07K16/40;C07K16/42;C07K19/00;G01N33/533;G01N33/541;G01N33/554;G01N33/566;(IPC1-7):A61K6/00 |
主分类号 |
C07K16/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|